Angiopoietin-like protein 3 (ANGPTL3) is also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANGPT5 / ANG-5), is a member of the angiopoietin-like family of secreted factors.
ANGPTL3 / ANGPT5 is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain.
The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration.
This protein may also play a role in the regulation of angiogenesis.
Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents.
ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels.
Circulating PL-riched HDL particles have high cholesterol efflux abilities.
特徴
This protein carries a polyhistidine tag at the C-terminus.
This protein contains a furin-like convertase cleavage site, 221-RAPR-224, and will be partially processed into N and C-terminal fragment with calculated MW of 23.8 kDa and 28.8 kDa respectively.
The protein migrates as 60-70 kDa (full lengh), 35-43 kDa (C-terminal fragment) under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Mouse Angiopoietin-like 3, His Tag (AN3-M52H3) is expressed from human 293 cells (HEK293). It contains AA Ser 17 - Thr 455 (Accession # Q9R182-1).
