CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family.
CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose.
These reaction products are essential for the regulation of intracellular Ca2+.
The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications.
The CD38 protein is a marker of cell activation.
It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism.
CD38 has been used as a prognostic marker in leukemia.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 56.3 kDa.
The protein migrates as 65-75 under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：25ug
Source：FITC-Labeled Human CD38, Fc Tag (Cat. No. CD8-HF255) is expressed from human HEK293 cells. It contains AA Val 43 - Ile 300 (Accession # P28907-1). It is the FITC labeled form of Human CD38 Protein, Fc Tag (Cat. No. CD8-H5255).
