83-3825-33 Human CD38 Protein, Mouse IgG2a Fc Tag, low endotoxin 50ug CD8-H5253-50ug
特徴
- 背景
- CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family.
- CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
- CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose.
- These reaction products are essential for the regulation of intracellular Ca2+.
- The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications.
- The CD38 protein is a marker of cell activation.
- It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism.
- CD38 has been used as a prognostic marker in leukemia.
- 特徴
- This protein carries a mouse IgG2a Fc tag at the C-terminus.
- The protein has a calculated MW of 56.9 kDa.
- The protein migrates as 65-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
- 容量：50ug
- Source：Human CD38, Mouse IgG2a Fc Tag (CD8-H5253) is expressed from human 293 cells (HEK293). It contains AA Val 43 - Ile 300 (Accession # P28907-1).
- Species Reactivity：Human
- Host：HEK293
- Tag：C-mFc(mIgG2a)
- Exp Region：Val 43 - Ile 300
- Format：Powder
- Conjugate：Unconjugated
- Swiss-Prot：P28907-1
- Protein ID：NP_001766.2
- Endotoxin：0.1 EU per μg
- Purity：95%
- Buffer：50 mM Tris, 100 mM Glycine, pH7.5
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