83-3825-05　Human Angiopoietin-like 3 / ANGPTL3 Protein, His Tag 100ug　AN3-H52H3-100ug

特徴

• 背景
• Angiopoietin-like protein 3 (ANGPTL3) is also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANGPT5 / ANG-5), is a member of the angiopoietin-like family of secreted factors.
• ANGPTL3 / ANGPT5 is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain.
• The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration.
• This protein may also play a role in the regulation of angiogenesis.
• Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents.
• ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels.
• Circulating PL-riched HDL particles have high cholesterol efflux abilities.
• 特徴
• This protein carries a polyhistidine tag at the C-terminus.
• This protein contains a furin-like convertase cleavage site, 221-RAPR-224, and will be partially processed into N and C-terminal fragment with calculated MW of 24.3 kDa and 29.4 kDa respectively.
• The protein migrates as 55-70 kDa (full lengh), 31-33 kDa (C-terminal fragment) when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.