T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3.
CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain.
CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction.
CD4 induces the aggregation of lipid rafts.
CD4 is a primary receptor used by HIV-1 to gain entry into host T cells.
HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors.
Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag).
The protein has a calculated MW of 69.7 kDa.
The protein migrates as 80 kDa under reducing (R) condition, and 150 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：Biotinylated Human CD4, Fc,Avitag (CD4-H82F3) is expressed from human 293 cells (HEK293). It contains AA Lys 26 - Pro 396 (Accession # P01730-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc & C-Avi
Exp Region：Lys 26 - Pro 396
Format：Powder
Conjugate：Biotin-labeled
Swiss-Prot：P01730-1
Protein ID：NP_000607.1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
