Prominin-1 is also known as CD133, Antigen AC133, PROM1, PROML1 and MSTP061.
Is used as marker for hematopoietic stem and progenitor cells (HSPC) for somatic stem cell isolation.
May play a role in cell differentiation, proliferation and apoptosis .
Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells.
During early retinal development acts as a key regulator of disk morphogenesis.
Involved in regulation of MAPK and Akt signaling pathways.
In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.
特徴
The CD133 carries a polyhistidine tag at the C-terminus with calculated MW of 97.2 kDa and migrates as 100-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
The membrane scaffold protein (MSP1D1) has calculated MW of 24.7 kDa, and it migrates as 25 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：20ug
Source：Human CD133 Full Length, His Tag (Nanodisc) (CD3-H52H1) is expressed from human 293 cells (HEK293). It contains AA Gly 20 - His 865 (Accession # O43490-1).
