83-3824-33　Mouse Angiopoietin-2 / ANGPT2 Protein, His Tag 100ug　AN2-M52H3-100ug

特徴

• 背景
• Angiopoietin-2 is also known as ANGPT2, AGPT2, ANG2, and is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation.
• Ang2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus.
• It is particularly abundant in vascular endothelial cells (EC) where it is stored in intracellular Weibel Palade bodies.
• Both Ang2 and the related Angiopoietin1 (Ang1) are ligands for the receptor tyrosine kinase Tie 2.
• Ang2 functions as a proangiogenic factor, although it can also induce EC death and vessel regression.
• Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells.
• Ang2 is required for postnatal vascular remodeling, and it cooperates with Ang1 during lymphatic vessel development.
• It mediates the upregulation of ICAM1 and VCAM1 on EC, which facilitates the adhesion of leukocytes during inflammation.
• Ang2 competitively inhibit Ang1-induced endothelial cell responses mediated by Tie2, and reduces vascular integrity.
• But the role of Ang2 is controversial since the opposite outcomes has been reported in other studies.
• Over-expression of Ang2 disrupts the vascular remodeling, induce endothelial cell apoptosis, and may play an important regulating role in tumor angiogenesis.
• Ang2 also promotes the neuronal differentiation and migration of subventricular zone progenitor cells.
• 特徴
• This protein carries a polyhistidine tag at the C-terminus.
• The protein has a calculated MW of 56.5 kDa.
• The protein migrates as 60-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.