Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains.
CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues.
CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role.
It is a ligand for integrin alpha-E/beta-7.
E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production.
Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 92.3 kDa.
The protein migrates as 100 kDa and 120 kDa (Cadherin), and 48 kDa (Propeptide) under reducing (R) condition (SDS-PAGE) due to different glycosylation.
仕様
容量：100ug
Source：Human E-Cadherin, Fc Tag (ECD-H5250) is expressed from human 293 cells (HEK293). It contains AA Gln 23 - Pro 621 (Accession # AAI41839).
