Human CD30 is also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.
TNFRSF-8 is expressed by activated, but not by resting, T and B cells.
Also, CD30 is expressed on classical Hodgkin Lymphoma cells together with CD15.
CD30 is the receptor for TNFSF8/CD30L.
CD30 can interact with TRAF2 and TRAF5, and mediate the signal transduction that leads to the activation of NF-kappa-B.
TNFRSF8 may play a role in the regulation of cellular growth and transformation of activated lymphoblasts.
TNFRSF8 is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 64.6 kDa.
The protein migrates as 80-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human CD30, Fc Tag (CD0-H5250) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Lys 379 (Accession # NP_001234.2).
