CD200 is also known as OX-2 membrane glycoprotein (OX-2), is a type-1 membrane glycoprotein, which contains two immunoglobulin domains (1 Ig-like C2-type (immunoglobulin-like) domain and Ig-like V-type (immunoglobulin-like) domain), and thus belongs to the immunoglobulin superfamily.
CD200 / OX-2 is widely expressed in multiple cell types.
CD200 interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function.
OX-2 / CD200 and CD200R associate via their respective N-terminal Ig-like domains.
CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 48.6 kDa.
The protein migrates as 55-68 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human CD200, Fc Tag (OX2-H5251) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Gly 232 (Accession # AAH22522).
