Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL).
BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family.
BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes.
BCL2L1 is a potent inhibitor of cell death.
BCL2L1 Inhibits activation of caspases.
BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane.
BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 24.6 kDa.
The protein migrates as 25-27 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：1mg
Source：Human Bcl-x, His Tag (BC1-H5120) is expressed from E. coli cells. It contains AA Met 1 - Arg 212 (Accession # AAH19307).
