Class I-restricted T cell-associated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory T-cell molecule, which is expressed by activated CD8+ and NK T cells.
CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum.
The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions (3 - 5).
IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production (3, 4).
Furthermore, a role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 56.6 kDa.
The protein migrates as 66-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Cynomolgus CRTAM, Fc Tag (CRM-C5255) is expressed from human 293 cells (HEK293). It contains AA Ser 18 - Gly 287 (Accession # XP_005580021.1).
Species Reactivity：Cynomolgus
Host：HEK293
Tag：C-Fc
Exp Region：Ser 18 - Gly 287
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：G7PPC7
Protein ID：XP_005580021.1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
