CD47 is very broadly distributed on normal adult tissues.
CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity.
CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 40.5 kDa.
The protein migrates as 55-66 kDa under reducing (R) condition, and 100-120 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Cynomolgus / Rhesus macaque CD47, Fc Tag (CD7-C5252) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Glu 141 (Accession # F7A802-1). In the region Gln 19 - Glu 141, the AA sequence of Cynomolgus and Rhesus macaque CD47 are homologus.
Species Reactivity：Cynomolgus / Rhesus macaque
Host：HEK293
Tag：C-Fc
Exp Region：Gln 19 - Glu 141
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：F7A802-1
Protein ID：NP_001253446.1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
