83-3821-39　Human ACE2 / ACEH Protein, His Tag （MALS verified） 1mg　AC2-H52H4-1mg

特徴

• 背景
• Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family.
• ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7.
• ACE2 may be an important regulator of heart function.
• In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses.
• ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat.
• ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.
• 特徴
• This protein carries a polyhistidine tag at the N-terminus.
• The protein has a calculated MW of 85.5 kDa.
• The protein migrates as 90-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.