Natural killer cell receptor 2B4 is also known as NK cell type I receptor protein 2B4 (NKR2B4 or h2B4), SLAM family member 4 (SLAMF4), Signaling lymphocytic activation molecule 4, CD antigen CD244.
NKR2B4 / CD244 contains two Ig-like (immunoglobulin-like) domains.
CD244 is expressed in spleen, PBL, followed by lung, liver, testis and small intestine.
CD244 interacts with CD48.
Following phosphorylation, CD244 is able to recruit PTPN11/SHP-2 and SH2D1A/SAP.
SLAMF4 modulate other receptor-ligand interactions to enhance leukocyte activation.
CD244/2B4 is the only heterophilic receptor of SLAM family.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag).
The protein has a calculated MW of 50.7 kDa.
The protein migrates as 65-80 kDa under reducing (R) condition, and 130-160 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：Biotinylated Human 2B4, Fc,Avitag (2B4-H82F0) is expressed from human 293 cells (HEK293). It contains AA Cys 22 - Arg 221 (Accession # Q9BZW8-2).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc & C-Avi
Exp Region：Cys 22 - Arg 221
Format：Powder
Conjugate：Biotin-labeled
Swiss-Prot：Q9BZW8-2
Protein ID：NP_057466.1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
