The TERT/PAX5/SMAD6 FISH Probe Kit is designed to detect the human TERT gene located on chromosome band 5p15.33, the PAX5 gene on chromosome band 9p13.2, and the SMAD6 gene on chromosome band 15q22.31.
Abnormal expression of the TERT gene – also known as TP2, TRT, CMM9, EST2, TCS1, hTRT, DKCA2, DKCB4, hEST2 or PFBMFT1 – have been reported in a variety of tumor types.
Rearrangements and abnormal expression of the PAX5 gene – also known as ALLL3, BSAP, or PAX-5 – have been observed in acute lymphoblastic leukemia （ALL） and in other lymphoproliferative disorders.
Abnormalities in SMAD6 – also known as MADH7, MADH6, HsT17432, or AOVD2 – are associated with cardiac valve defects, developmental deficiencies, lung neoplasms and other malignancies.
