The CTNND2/EGR1 FISH Probe Kit is designed to detect the human CTNND2 gene located on chromosome band 5p15.2, and the EGR1 gene on chromosome band 5q31.2.
Abnormal expression of the CTNND2 gene – also known as GT24 or NPRAP – has been observed in brain and prostate carcinoma and other solid tumor types.
Abnormalities in EGR1 – also known as TIS8, AT225, G0S30, NGFI-A, ZNF225, KROX-24 or ZIF-268 – have been observed in myeloid malignancies, fibrosarcoma, lung, brain, breast, skin, prostate liver and various other cancer types.
Deletions in the CTNND2 gene region are found in the rare genetic disorder Cri du Chat syndrome.
