The NTRK1,2,3 Break Apart FISH Probe Kit is designed to detect earrangements in the human NTRK1 gene located on chromosome band 1q23.1, the NTRK2 gene located on chromosome band9q21.33 and the NTRK3 gene located on chromosome band15q25.3.
Rearrangements and abnormal expression of the NTRK1 gene – also known as MTC, TRK, TRK1, TRKA, Trk-A or p140-TrkA – have been observed in papillary thyroid carcinoma and other malignancies.
Rearrangements and abnormal expression of the NTRK2 gene – also known as OBHD, TRKB, DEE58, trk-B, EIEE58 or GP145-TrkB –have been observed in neuroblastoma, pancreatic ductal adenocarcinoma, Wilms' tumors and colorectal cancer, and a number of developmental and metabolic disorders.
Rearrangements and abnormal expression of the NTRK3 gene – also known as TRKC, GP145-TrkC or gp145（trkC）– have been observed in medulloblastoma, fibrosarcoma, nephroma, some breast carcinoma subtypes and other malignancies.
