The ZFTA Break Apart FISH Probe Kit is designed to detect rearrangements in the human ZFTA gene located on chromosome band 11q13.1.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other ZFTA aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the ZFTA gene – also known as C11orf95 – have been associated with anaplastic ependymoma, ependymoma, breast invasive ductal carcinoma, clear cell ependymona and other malignancies.
