The SNRPN/PML FISH Probe Kit is designed to detect the human SNRPN gene located on chromosome band 15q11.2, along with the human PML gene located on chromosome band 15q24.1.
Altered expression of the SNRPN gene – also known as SMN, PWCR, SM-D, sm-N, RT-LI, HCERN3, SNRNP-N, SNURF-SNRPN – has been observed in some solid tumor types.
Paternal copy deletion of this gene is observed in Prader-Willi Syndrom （PWS） individuals.
Rearrangements involving PML are found in various malignancies.
