TheNTRK2 Break Apart FISH Probe Kitis designed to detect rearrangements in the human NTRK2 gene located on chromosome band9q21.33.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other NTRK2 aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the NTRK2 gene – also known as OBHD, TRKB, DEE58, trk-B, EIEE58 or GP145-TrkB –has been observed in neuroblastoma, pancreatic ductal adenocarcinoma, Wilms' tumors and colorectal cancer, and a number of developmental and metabolic disorders.
