The CSF1R Break Apart FISH Probe Kit is designed to detect rearrangements in the human CSF1R locus mapping to chromosome band 5q32.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other CSF1R aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the CSF1R gene – also known as IFMS, CSFR, FIM2, HDLS, C-FMS, CD115, CSF-1R, or M-CSF-R - have been observed in acute megakaryoblastic leukemia （AMKL）, myelodysplastic syndrome （MDS）, breast and cervical and other cancers.
