The SMARCB1 Break Apart FISH Probe Kit is designed to detect rearrangements in the human SMARCB11 gene mapping to chromosome band 22q11.23.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other SMARCB1 aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the SMARCB11 gene – also known as RDT, CSS3, INI1, SNF5, Snr1, BAF47, MRD15, RTPS1, Sfh1p, hSNFS, SNF5L1, SWNTS1 or PPP1R144 – have been observed in rhabdoid tumors and other malignancies and neoplastic predisposition syndromes.
