TheNSD1/D5S23,D5S721 FISH Probe Kitis designed to detect the human NSD1 gene located on chromosome band 5q35.3, along with the human D5S23,D5S721 region located on chromosome band 5p15.2.
Abnormal expression or rearrangements of the NSD1 gene – also known asSTO, KMT3B, SOTOS, ARA267 or SOTOS1– have been observed inacute myeloid leukemia （AML）, other neoplasms and some inherited defects such as Sotos syndrome and Weaver syndrome.
