TheNSD1/TERT FISH Probe Kitis designed to detect the human NSD1 gene located on chromosome band 5q35.3, along with the human TERT gene on chromosome band 5p15.33.
Gains and losses of portions of the TERT gene – also known as TP2, TRT, CMM9, EST2, TCS1, hTRT, DKCA2, DKCB4, hEST2 or PFBMFT1 – have been reported in a variety of tumor types.
Abnormal expression or rearrangements of the NSD1 gene – also known as STO, KMT3B, SOTOS, ARA267 or SOTOS1– has been observed inacute myeloid leukemia （AML）, other neoplasms and some inherited defects such as Sotos syndrome and Weaver syndrome.
