The BAP1/CCP3 FISH Probe Kit is designed to detect the human BAP1 gene located on chromosome band 3p21.1, along with the number of chromosome 3 copies per cell.
Abnormalities in BAP1 – also known as UBM2, UVM2, KURIS, TPDS1, UCHL2, hucep-6 or HUCEP-13 – may be associated with tumor predisposition syndrome （TPDS）, which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.
