The IGH-MYC Dual Fusion/Translocation LR (long-range) FISH Probe Kit is designed to detect rearrangements involving the human IGH and MYC genes, located on chromosome bands 14q32.33 and 8q24.21, respectively.
IGH is also known as IGD1, IGH@, IGHJ, IGHV, IGHD@, IGHJ@, IGHV@, IGH.1@ or IGHDY1 and MYC is also known as MRTL, MYCC, c-Myc or bHLHe39.
Rearrangements involving portions of these two genes have been observed in several B-cell lymphoma subtypes, especially Burkitt lymphoma, and other malignancies.