TheCREBBP Break Apart FISH Probe Kitis designed to detect rearrangements in the human CREBBP gene located on chromosome band 16p13.3.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other CREBBP aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the CREBBP gene – also known as CBP, RSTS, KAT3A or RSTS1 – have been observed in acute nonlymphocytic leukemia （AML） and other malignancies and in some developmental disorders.
