TheKAT6A Break Apart FISH Probe Kitis designed to detect rearrangements in the human KAT6A gene mapping to chromosome band 8p11.21.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other KAT6A aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the KAT6A gene – also known as MOZ, MRD32, MYST3, MYST-3, ZNF220, RUNXBP2 or ZC2HC6A – have been observed in acute non-lymphocytic （AML） and monocytic leukemias, myelodysplastic syndrome and other cancer types.
