TheMKL1 Break Apart FISH Probe Kitis designed to detect rearrangements in the human MKL1 gene mapping to chromosome band 22q13.1.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other MKL1 aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the MKL1 gene – also known as KIAA1438, MAL, MKL, BSAC or MRTF-A - have been observed in acute megakaryocytic leukemia and other hematological and solid tumor types.
