TheRBM15 Break Apart FISH Probe Kit is designed to detect rearrangements in the human RBM15 gene mapping to chromosome band 1p13.3.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other RBM15 aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the RBM15 gene – also known as OTT, OTT1 or SPEN - have been observed in acute megakaryocytic leukemia （AML） and other tumor types.
