The KIAA1549 Break Apart FISH Probe Kit is designed to detect rearrangements in the human KIAA1549 locus mapping to chromosome band 7q34.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other KIAA1549 aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the KIAA1549 gene – also known as RP86 –have been observed in astrocytomas and other solid tumor types.
