The RBM15-MKL1 Dual Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human RBM15 and MKL1 genes, located on chromosome bands 1p13.3 and 22q13.1, respectively.
RBM15 is also known as OTT, OTT1 or SPEN.
MKL1 is also known as KIAA1438, MAL, MKL, BSAC or MRTF-A.
Rearrangements involving portions of both genes have been observed in acute megakaryocytic leukemia and other hematological and solid tumor types.