The CBFB Break Apart FISH Probe Kit is designed to detect rearrangements in the human CBFB gene located on chromosome band 16q22.1.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other CBFB aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the CBFB gene – also known as CBFb or PEBP2B – have been observed in acute myeloid leukemia （AML） and other hematological malignancies.
