The RUNX1-RUNX1T1 Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human RUNX1 and RUNX1T1 genes located on chromosome bands 21q22.12 and 8q21.3, respectively.
Rearrangements involving portions of these two genes, the RUNX1 gene – also known as AML1, AML1-EVI-1, AMLCR1, CBFA2, EVI-1 or PEBP2aB – and the RUNX1T1 gene – also called AML1-MTG8, AML1T1, CBFA2T1, CDR, ETO, MTG8 or ZMYND2, have been observed in acute non-lymphocytic leukemia and many other hematological malignancies.
