The BCR-ABL1 Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human BCR and ABL1 genes located on chromosome bands 22q11.23 and 9q34.12, respectively.
A reciprocal translocation between the two genes is present in virtually all cases of chronic myelocytic leukemia （CML）, but also occurs in a subset of pediatric and adult acute lymphocytic leukemias （ALL）, acute myelogenous leukemia （AML） and other malignancies.
