The CDC34/CD37 FISH Probe Kit is designed to detect rearrangements involving the human CDC34 gene located on chromosome band 19p13.3, along with the region around CD37 gene located on chromosome band 19q13.33 measuring the integrity of chromosome 19.
Abnormal expression of the two genes （the CDC34 gene – also called UBC3, UBCH3, UBE2R1 or E2-CDC34 – and the CD37 gene – also called GP52-40 or TSPAN26 –） is upregulated in Burkitt's lymphoma and other B-cell malignancies, and expressed in a number of solid tumor types as well.
