The EWSR1-FLI1 Tri-color Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human EWSR1 and FLI1 genes, located on chromosome bands 22q12.2 and 11q24.3, respectively.
EWSR1 is also known as EWS, EWS-FLI1 or bK984G1.
FLI1 is also known as EWSR2, SIC-1 or BDPLT21.
Rearrangements involving portions of these two genes have been observed in Ewing's and other sarcomas, nervous system and other tumors, and in some congenital and autoimmune conditions.