The CRLF2/CCPX FISH Probe Kit is designed to detect the human CRLF2 gene located on chromosome bands Xp22.33 and Yp11.23, along with the number of chromosome X copies per cell.
Rearrangements and abnormal expression of the CRLF2 gene – also known as CRL2, TSLPR or CRLF2Y – have been observed in adult and pediatric acute lymphoblastic leukemia (ALL) and various other malignancies.