The RREB1/MYB/CCP6/CCND1 FISH Probe Kit is designed to detect the human RREB1, MYB and CCND1 genes located on chromosome bands 6p24.3, 6q23,3 and 11q13.3, respectively, along with the number of chromosome 6 copies per cell.
Abnormal expression of the RREB1 gene – also known as Zep-1, RREB-1, LZ321, HNT or FINB –, the MYB gene – also called efg, Cmyb, c-myb or c-myb_CDS – and the CCND1 gene – also recognized as BCL1, D11S287E, PRAD1 or U21B31 – have been observed in colorectal and pancreatic cancer, melanoma and other malignancies.
