The TGFBR3-MGEA5 Dual Fusion/Translocation FISH Probe Kit is designed to detect rearrangements involving the human TGFBR3 and MGEA5 genes, located on chromosome bands 1p22.1 and 10q24.32, respectively.
TGFBR3 is also known as BGCAN or betaglycan.
MGEA5 is also known as OGA, MEA5 or NCOAT.
Rearrangements involving portions of both genes are frequent in some fibroblastic and fibrolipomatous sarcomas and are also found in multiple myeloma and many other malignancies, including breast, colorectal, hepatocellular, oral, lung, prostate, ovarian, pancreatic and other cancers.
