TheNTRK3 Break Apart FISH Probe Kitis designed to detect rearrangements in the humanNTRK3gene located on chromosome band15q25.3.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify otherNTRK3aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of theNTRK3gene – also known asTRKC, GP145-TrkCorgp145（trkC）-has been observed inmedulloblastoma, fibrosarcoma, nephroma, some breast carcinoma subtypes and other malignancies.
