The IGK Break Apart FISH Probe Kit is designed to detect rearrangements in the human IGK locus mapping to chromosome band 2p11.2.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other IGK aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the IGK gene – also known as IGK@ - have been observed in various B-cell lymphoma subtypes and other malignancies.
