The MYC Break Apart LR （long-range） FISH Probe Kit probe set is designed to detect rearrangements involving regions of the human MYC gene located on chromosome band 8q24.
In addition to revealing breaks, which lead to translocation of parts or all of the gene or its fusion to other genes, the probe set can also be used to identify other MYC aberrations such as deletions, amplifications or chromosome 8 hyperdiploidy.
Rearrangements and abnormal expression of the MYC gene – also known as MRTL, MYCC, c-Myc or bHLHe39– have been observed in Burkitt's Lymphoma and other hematological malignancies, myeloma, as well as breast, cervical, colon, ovarian and other tumor types.
