TheSTAT6 Break Apart FISH Probe Kitis designed to detect rearrangements in the human STAT6 gene mapping to chromosome band 12q13.3.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other STAT6 aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the STAT6 gene – also known as STAT6B, STAT6C, D12S1644 or IL-4-STAT – have been observed in liposarcoma, solitary fibrous tumors and other mesenchymal neoplasms.
