TheMLLT1 Break Apart FISH Probe Kitis designed to detect rearrangements in the humanMLLT1gene mapping to chromosome band 19p13.3.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify otherMLLT1aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of theMLLT1gene – also known as ENL, LTG19 or YEATS1 - have been observed in acute leukemias and other tumor types.
