The CCND1 Break Apart FISH Probe Kit is designed to detect rearrangements in the human CCND1 gene located on chromosome band 11q13.3.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other CCND1 aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the CCND1 gene – also known as BCL1, PRAD1, U21B31 or D11S287E – have been observed in several types of hematological malignancies.
