The MYC Break Apart FISH Probe Kit is designed to detect rearrangements in the human MYC gene located on chromosome band 8q24.21.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other MYC aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the MYC gene – also known as MRTL, MYCC, c-Myc or bHLHe39 – have been observed in Burkitt's Lymphoma and other hematological malignancies, myeloma, as well as breast, cervical, colon, ovarian and other tumor types.
