The TCF3 Break Apart FISH Probe Kit is designed to detect rearrangements in the human TCF3 gene located on chromosome band 19p13.3.
In addition to revealing breaks, which can lead to translocation of parts of the gene, inversion, or its fusion to other genes, the probe set can also be used to identify other TCF3 aberrations such as deletions or amplifications.
Rearrangements and abnormal expression of the TCF3 gene – also known as E2A, E47, ITF1, VDIR, TCF-3 or bHLHb21 – have been observed in adult and pediatric B-cell leukemias and other tumor types.
