The RB1/CCP11 FISH Probe Kit is designed to detect the human RB1 gene located on chromosome band 13q14.2, along with the number of chromosome 11 copies per cell.
Abnormal expression of the RB1 gene – also known as RB, pRb, OSRC, pp110, p105-Rb or PPP1R130 – and aneuploidy of the chromosome 11 have been observed in retinoblastoma, sarcomas and various other heritable and somatic tumor types.
Concurrent deletions of RB1 and the 11q chromosome arm are frequent in some B-cell lymphomas.
